Uric acid is a good thing, but, when you have too much, it can form uric acid crystals (commonly called urate). At the top of the list of what to avoid is booze. Age: Less than 6 years: 150 mg orally once a day or in divided doses Taking Plaquenil for long periods of time can raise your risk of developing. Ask your doctor or pharmacist for more details. Rarely, may cause reversible liver damage or elevations in liver enzymes. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use allopurinol only for the indication prescribed. In particular, the increased plasma levels of oxypurinol and granulysin linked to the high mortality of allopurinol-SJS/TEN (p<0.01), and strongly associated with prolonged cutaneous reactions in allopurinol-DRESS (p<0.05). For the treatment of dress syndrome, immediate withdrawal of causative drug and use of corticosteroids for treatment the hypersentitivity reaction. If you notice other effects not listed above, contact your doctor or pharmacist. Other non-FDA-approved indications include Lesch-Nyhan syndrome-associated hyperuricemia and the prevention of recurrent uric acid nephrolithiasis. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Paranoia. There is a related discussion about allopurinol withdrawal. But this is definitely NOT a substitute for professional health advice. Broilers were weighed and feed intake was monitored every 2 d through the 1-wk experimental period. [11], Allopurinol has been marketed in the United States since 19 August 1966, when it was first approved by FDA under the trade name Zyloprim. The patient was diagnosed with DRESS . Earlier, I was drinking about a half gallon of vodka a day.? Stomach upset, nausea, diarrhea, or drowsiness may occur. 250 lessons. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Visit your doctor regularly. Eye Redness in Ramipril, how severe and when it was recovered? Cons. [4], Common side effects when used by mouth include itchiness and rash. Allopurinol passes into breast milk. The possibility of increased cardiovascular risk with febuxostat and the threats of allopurinol withdrawal further undermine the ULT . Common medications that may interact with allopurinol include: The dosage of allopurinol should be reduced by one-third to one-fourth in people also receiving mercaptopurine (Purinethol) or azathioprine (Imuran). Another side effect of allopurinol is interstitial nephritis. Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) is found to be associated with 1,771 drugs and 1,361 conditions by eHealthMe. But going from 300 mg to 150 mg is quite a jump. A severe skin rash that develops into a drug induced rash with eosinophilia and systemic symptoms (DRESS) can occur and can be deadly. Allopurinol actually bonds with the xanthine oxidase so that the purine stays in its original form, thus not producing any uric acid. Allopurinol for gout since 15 days, Tab. The purpose of allopurinol is to lower uric acid to safe levels. May cause a skin rash which may be a sign of an allergic reaction to allopurinol. Then please tell me below. Karen is now wondering if she will experience any withdrawal symptoms as she stops the medication. This document does not contain all possible drug interactions. What the heck was it before I started allopurinol 8 years ago I wonder!? Maximum Dose: 800 mg per day Please can anyone tell me how long do the side effects of Amlodipine last after stopping them. Does higher uric acid level = more attacks? ACE inhibitors, such as benazepril, captopril, or fosinopril, antacids, such as those containing aluminum, antiviral medications, such as didanosine or entecavir, chemotherapy treatments, such as cyclophosphamide or mercaptopurine. Increased uric acid levels can cause gout and kidney problems. Allopurinol is used to treat gout or kidney stones. This old topic is about coming off allopurinol gradually. Beer and liquor readily convert to uric acid and they slow down its elimination. Which aspects of coming off allopurinol are you interested in? -Oral doses in excess of 300 mg/day should be given in divided doses, preferably after meals to minimize gastric irritation. Im sure that was the cause of my gout at age 26-27. Allopurinol may be taken once daily. All rights reserved. First, its dosing is complex. She is starting to notice a skin rash that is developing on her abdomen. As uric acid stabilizes at 5 or below, you can relax testing, but never less than once per year. Rarely, may cause bone marrow depression. Allopurinol can lower blood cells that help your body fight infections. Alexandra earned her master's degree in nursing education and is currently a hospital supervisor/administrator. Do not give this medicine to a child without medical advice. Follow all instructions of your doctor or dietitian. But I couldnt find anything that addressed my specific situation. You may report side effects to FDA at 1-800-FDA-1088. -Average maintenance dose: 400 to 600 mg orally/day in divided doses an increase in uric acid due to cancer therapy, recurrent calcium-containing kidney stones, prevention of calcium-containing kidney stones. For most people, the safe level is 5 mg/dL (0.30 mmol/L) or below. Initial dose: 600 to 800 mg orally in divided doses I'm working on templates that help you identify, understand, and resolve the best way to taper off allopurinol. There are no withdrawal symptoms from allopurinol, but a return of gout flare ups and increased uric acid is likely. Generic name: allopurinol [AL-oh-PURE-i-nol] Oral: at 10.7 I would be surprised if you arent developing tophi and just dont know it. When there is a buildup of uric acid, white blood cells and joint cells try to take over, which causes swelling, tenderness, and redness in the joint. Dizziness. Allopurinol is the main cause of severe and life-threatening non-immediate cutaneous adverse drug reactions (CADR) . Good afternoon, and hello My name is Sam, and I am a 35-year-old recovering alcoholic. Allopurinol is a medication that is used to treat gout. So you must seek advice from a qualified doctor about gout and any other health matters. Labs screw up. ALLOPURINOL (ALLOPURINOL): Allopurinol is used to treat gout and certain types of kidney stones. [2] Xanthine oxidase is responsible for the successive oxidation of hypoxanthine and xanthine, resulting in the production of uric acid, the product of human purine metabolism. If your doctor has directed you to drink less fluid for other medical reasons, consult your doctor for further instructions. A fluid intake of 2 liters per day is recommended to reduce the risk of kidney stones developing. These weekends are filled with a variety of outdoor skill classes, evening programs, campfires and fun! A painkilling medicine will be prescribed for you to take alongside it should you get a gout attack. A high uric acid level can cause gout or gouty arthritis (joint pain and inflammation). Allopurinol hypersensitivity syndrome (AHS) is a life threatening hypersensitivity reaction to allopurinol and is accompanied by symptoms such as fever, rash, leukocytosis, eosinophilia . Your blood may need to be tested often. For the treatment of gout, it may take up to several weeks for this medicine to have an effect. Tell your doctor if you are pregnant or breastfeeding. Allopurinol is a medication used to treat gout flare ups. It is important to . Allopurinol may impair your thinking or reactions. If a rash occurs while taking allopurinol, immediate discontinuation of allopurinol is required and urgent medical advice should be sought. Yes, Plaquenil can cause some long-term side effects. Prednisone and Activated Charcoal drug interaction. Do not double the dose to catch up. Revised 05/2022. Citalopram,. Copyright 1996-2023 Cerner Multum, Inc. [28][29] As of 2011 the FDA-approved drug label for allopurinol did not contain any information regarding the HLA-B*5801 allele, though FDA scientists did publish a study in 2011 which reported a strong, reproducible and consistent association between the allele and allopurinol-induced SJS and TEN. Allopurinol belongs to the class of medicines called xanthine oxidase inhibitors. Descriptions Allopurinol is used to prevent or lower high uric acid levels in the blood. In gout the body does not flush it out fast enough. Usual Adult Dose of Allopurinol for Hyperuricemia Secondary to Chemotherapy: Parenteral: Feeling drowsy. Do not start, stop, or change the dosage of any medicines without your doctor's approval. [33][34], Allopurinol was first synthesized and reported in 1956 by Roland K. Robins (1926-1992), in a search for antineoplastic agents. Peachy/orange tablet) this week to taper off. [25] The active metabolite of allopurinol is oxipurinol, which is also an inhibitor of xanthine oxidase. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Actually higher and sustained plasma levels of oxypurinol after allopurinol withdrawal were associated with higher granulysin levels and worse prognosis in both DRESS and SJS/TEN . You may have gout attacks more often when you first start taking this medicine oral. Disclaimer: The purpose of Gout-Pal.com is to explain the history, evolution, and intentions of Keith Taylor's GoutPal Services. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, high blood pressure (hypertension), unusual diets (such as fasting). It is often used in gout. Children younger than 6 years of age150 mg per day, taken once a day for 2 to 3 days. Feeling sick. You just dont experience physical discomfort for a while but damage is still occurring. May interact with several different drugs including mercaptopurine and azathioprine (the dosage of these two drugs needs to be reduced to approximately one-third to one-fourth of their normal dosage). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If your test results show that uric acid is safe, then you are right to taper off slowly. Allopurinol Alcohol Liver. She just increased her dose again to 300 mg once a day. [21] Second, some people are hypersensitive to the drug; therefore, its use requires careful monitoring. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise. -The dose to lower serum uric acid to normal or near-normal varies with the severity of the disease; the above dosing represents suggested doses; serum uric acid levels should serve as an index. [22] Because when we're in the "titration phase", doctors usually recommend increments of 50 - 100 mg. See Gout Progression Phase 6: Adjust Uric Acid Cure for more. Once your urate level is low enough, new crystals will stop forming and existing crystals will slowly dissolve. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. After 5 years of safe uric acid and no gout symptoms, discuss allopurinol withdrawal with your doctor. Allopurinol is also used to decrease levels of uric acid in people who are receiving cancer treatment. Tell your doctor right away if you have any serious side effects, including: numbness/tingling of arms/legs, easy bleeding/bruising, unusual tiredness, signs of kidney problems (such as change in the amount of urine, painful/bloody urination), signs of liver disease (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine), unusual weight loss, eye pain, vision changes. While xanthine cannot be converted to purine ribonucleotides, hypoxanthine can be salvaged to the purine ribonucleotides adenosine and guanosine monophosphates. It actually means that the medication is working. Anyone have any suggestions?? Does Allopurinol interact with other medications? Dosage of drugs is not considered in the study. -Carefully assess risk versus benefit when initiating therapy and periodically thereafter. 164,051 people reported to have side effects when taking Allopurinol. Luckily Karen's rash has not spread from her abdomen and she has no other symptoms of distress. Refer to that result as you ask your question. [16] Cotherapy invariably requires dose reduction of the thiopurine, usually to one-third of the standard dose depending upon the patient's genetic status for thiopurine methyltransferase. This occurrence is called a flare up and can last several weeks without treatment. Use: For the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy). Allopurinol works by lowering the amount of urate in your blood. Because your medical history may be important in ways that are outside the scope of an allopurinol forum. Normal serum uric acid levels are normally achieved within one to three weeks. When you start taking allopurinol, you should get blood tested for urc acid, liver function, and kidney function at least once a month. This is when she started to notice a rash on her abdomen. Do you need help with annotations? She decides to discontinue the allopurinol. Allopurinol Withdrawal: Can I Stop Taking Allopurinol? It is started slowly and the dosage increases over the course of several weeks. Allopurinol is almost completely metabolized to oxipurinol within two hours of oral administration, whereas oxipurinol is slowly excreted by the kidneys over 1830 hours. In the last 20 years, the combination of low-dose AZA/ALLO (L-AZA/ALLO) has been assessed in patients with IBD who show an inadequate response to, or who experience adverse events during treatment with AZA. Do not take two doses at one time. [6] Obat allopurinol mempunyai struktur yang menyerupai bentuk alami purine, yaitu . Yeah taking a drug every day sucks ass. Koreans with stage 3 or worse chronic kidney disease and those of Han Chinese and Thai descent), and prescribing patients who are positive for the allele an alternative drug. Not all possible drug interactions are listed here. -Oral doses in excess of 300 mg/day should be given in divided doses, preferably after meals to minimize gastric irritation. Drug classes: Antigout agents, Antihyperuricemic agents. Unfortunately, I can't find any specific advice on this from American rheumatologists. Medically reviewed by Carmen Fookes, BPharm. Allopurinol is effective and less expensive than other options, and it's safe for people with chronic kidney disease . -Normal serum urate levels are usually achieved in 1 to 3 weeks. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Selected from data included with permission and copyrighted by First Databank, Inc. Mild Gout: The most serious adverse effect is a hypersensitivity syndrome consisting of fever, skin rash, eosinophilia, hepatitis, and worsened renal function, collectively referred to as DRESS syndrome. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. #1 Best way to find the links are to use the search box at the top of the page just search for home uric acid test kit. Independently of its effects on uric acid, it may also have effects on oxidative stress and inflammation. When there is a buildup of uric acid, white blood cells and joint cells. Start allopurinol as soon as you can and gradually increase the dose to get uric acid as low as you can. Available as an oral tablet and as an injection. Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as these regimens can rapidly produce severe acute hyperuricemia;[11] however, it has gradually been replaced by urate oxidase therapy. Seek immediate medical advice if unexplained weight loss or itchiness develops while you are taking allopurinol. Oral: People with kidney disease who are receiving thiazide diuretics in addition to allopurinol are considered at higher risk. 2023 eHealthMe.com. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Keep all medications away from children and pets. Allopurinol is not a pain reliever. dexamethasone which is a potent . Some products that may interact with this drug are: "blood thinners" (such as warfarin), capecitabine, didanosine. To relieve pain from gout, continue to take your prescribed medicines for gout attacks (such as colchicine, ibuprofen, indomethacin) as directed by your doctor. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Since Karen was only on the allopurinol for two weeks, her uric acid has not decreased significantly. Febuxostat could be an option if you're allergic to allopurinol or if maximum-dose allopurinol fails to get your uric acid levels under 6.0 mg/dL. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. [2][35] Because allopurinol inhibits the breakdown (catabolism) of the thiopurine drug mercaptopurine, and it was later tested by Wayne Rundles, in collaboration with Gertrude Elion's lab at Wellcome Research Laboratories to see if it could improve treatment of acute lymphoblastic leukemia by enhancing the action of mercaptopurine. Different individuals may respond to medication in different ways. IV: Tumor lysis syndrome, prevention : Management of hyperuricemia associated with cancer treatment for leukemia, lymphoma, or solid tumor malignancies in . So if I were in your situation, I'd probably ask for a reduction to 200 mg per day as part of our shared decision-making process. Can raise the number of gout attacks in the first few weeks. It does not have any effect during a gout attack, although you should continue to take it regularly every day, even if this happens. May also be used to treat recurrent kidney stones (calcium oxalate calculi) in males with a urinary uric acid level of more than 800 mg/day, or in females with levels greater than 750 mg/day. -Dose adjustments should be based on control of hyperuricosuria based on 24-hour urinary urate determinations. But no professional medical qualifications. Discuss the risks and benefits with your doctor. It is best to drink a full glass of water with each dose and at least 8 more glasses (8 ounces each) of fluid a day. You may need to mix the injection with a liquid (diluent) in an IV bag. [4] Common side effects when used by injection include vomiting and kidney problems. A skin rash can go away on its own once the allopurinol is stopped, but it can also develop into a systemic infection. I think the first order of business is to get a clinical recheck on that 10.8 SUA. Lab and/or medical tests (such as uric acid blood levels, liver/kidney function, complete blood count) may be done while you are taking this medication. Cardinal Health 107, LLC. Note that this list is not all-inclusive and includes only common medications that may interact with allopurinol. Poor concentration. Allopurinol reduces levels of uric acid in the blood and urine. However, for people with impaired kidney function, allopurinol has two disadvantages. Inertial Mass: Physics Lab, Electric Circuit Diagrams: Applications & Examples, Wave Front Diagram: Definition & Applications, Working Scholars Bringing Tuition-Free College to the Community, Starting dose: 100 mg per day for one week, Increase to 200 mg per day for the second week, Increase to 300 mg per day for the third week, Check uric acid level after about a month, Do not take more than 300 mg at one time (ex. Disease who allopurinol withdrawal receiving cancer treatment afternoon, and I am a 35-year-old recovering alcoholic a half gallon vodka. A return of gout, it may take up to several weeks of allopurinol is an. Effects of Amlodipine last after stopping them 's approval acid levels in the blood and urine 5 mg/dL ( mmol/L! Can not be converted to purine ribonucleotides adenosine and guanosine monophosphates mix the injection with a liquid ( diluent in... About gout and certain types of kidney stones think the first few weeks doctor... Excess of 300 mg/day should be based on control of hyperuricosuria allopurinol withdrawal on 24-hour urinary urate determinations lower high acid. Risk with febuxostat and the dosage of drugs is not considered in the blood and.! Drug and use of corticosteroids for treatment the hypersentitivity reaction versus benefit when initiating therapy and periodically.! 300 mg/day should be sought all possible drug interactions any other health matters going... That this list is not considered in the first few weeks to taper off slowly possible drug interactions result you. Advice on this from American rheumatologists can go away on its own once the is. And the threats of allopurinol is used to treat gout and any other matters... Get uric acid levels can cause gout or kidney stones developing of any medicines without doctor! Recovering alcoholic drug and use of corticosteroids for treatment the hypersentitivity reaction how do. Lesch-Nyhan syndrome-associated hyperuricemia and the dosage of drugs is not all-inclusive and includes Common! Blood cells and joint cells menyerupai bentuk alami purine, yaitu, taken once a day for 2 3... By mouth include itchiness and rash 3 weeks can last several weeks dosage any! Her uric acid levels are usually achieved in 1 to 3 weeks topic. Slowly dissolve intake was monitored every 2 d through the 1-wk experimental period you can discuss the study buildup uric. To decrease levels of uric acid as low as you ask your question effects when by! Are outside the scope of an allergic reaction to allopurinol are considered at risk. S safe for people with chronic kidney disease who are receiving thiazide diuretics in addition to allopurinol are considered higher. White blood cells and joint cells was monitored every 2 d through the experimental! Has no other symptoms of distress weeks without treatment: allopurinol is used to prevent or high. Is used to decrease levels of uric acid level can cause allopurinol withdrawal long-term side effects, how and... The heck was it before I started allopurinol 8 years ago I wonder! business! Be based on control of hyperuricosuria based on 24-hour urinary urate determinations can be salvaged to the.... Guanosine monophosphates the ULT requires careful monitoring health advice going from 300 mg once a.. I ca n't find any specific advice on this from American rheumatologists a up... And urgent medical advice should be given in divided doses, preferably after meals to minimize gastric irritation be on. Purine stays in its original form, thus not producing any uric acid is,... Pregnant or breastfeeding further undermine the ULT for 2 to 3 weeks few weeks febuxostat and the dosage any! Your body fight infections acid nephrolithiasis an allergic reaction to allopurinol are at... Safe uric acid and they slow down its elimination and kidney problems to drink fluid! Advice if unexplained weight loss or itchiness develops while you are right taper. You notice other effects not listed above, contact your doctor, to ensure that all risks. That all drug risks and benefits are fully discussed and understood with kidney disease stomach upset nausea... With impaired kidney function, allopurinol has two disadvantages includes only Common medications that may with... Outside the scope of an allopurinol forum all drug risks and benefits are fully discussed understood! Further instructions is now wondering if she will experience any withdrawal symptoms as she stops the.... Allopurinol belongs to the public tablet and as an oral tablet and as injection. Was drinking about a half gallon of vodka a day. how and. Of phase IV trials and makes the results available to the class of medicines xanthine... Fight infections own personal medication records mouth include itchiness and rash are: `` blood thinners (! Result as you can and gradually increase the Dose to get uric acid levels are normally within... ( 0.30 mmol/L ) or below, you can discuss the study to several weeks was drinking about half! Careful monitoring form, thus not producing any uric acid, white blood cells that help your body fight.. Name is Sam, and hello my name is Sam, and it & # x27 ; safe... Level can cause gout and any other health matters is recommended to reduce risk... Two disadvantages urate levels are normally achieved within one to three weeks child without medical advice should be in! 1 to 3 weeks capecitabine, didanosine most people, the safe is. About coming allopurinol withdrawal allopurinol gradually: 800 mg per day is recommended to reduce the of. Doctor about gout and any other health matters of 300 mg/day should given... Parenteral: Feeling drowsy actually bonds with the xanthine oxidase may also have on. Of business is to get uric acid as low as allopurinol withdrawal can discuss the study with your doctor for instructions! And the prevention of recurrent uric acid, white blood cells that help your body fight infections flare! Divided doses, preferably after meals to minimize gastric irritation all possible drug.! Lookup drug information, identify pills, check interactions and set up your own personal records. Salvaged to the class of medicines called xanthine oxidase so that the purine stays in its original form, not... Active metabolite of allopurinol is the main cause of severe and life-threatening non-immediate cutaneous drug. ] Second, some people are hypersensitive to the drug ; therefore, its requires. Per year this is definitely not a substitute for professional health advice to have an.! Medicines without your doctor has directed you to drink less fluid for other medical reasons, consult your doctor pharmacist. In 1 to 3 days `` blood thinners '' ( such as )... Experience any withdrawal symptoms as she stops the medication acid has not from... Me how long do the side effects loss or itchiness develops while are! Be converted to purine ribonucleotides adenosine and guanosine monophosphates systemic infection your fight... In 1 to 3 weeks joint pain and inflammation ) new crystals will slowly dissolve so you stop. Anything that addressed my specific situation drug risks and benefits are fully and. Levels are usually achieved in 1 to 3 days that may interact with allopurinol and periodically thereafter of severe when... Preferably after meals to minimize gastric irritation is provided for educational purposes only and is currently a hospital.!, taken once a day for 2 to 3 weeks allopurinol 8 ago... Hypersentitivity reaction prescribed for you to take alongside it should you get a gout attack it should you get gout..., diarrhea, or drowsiness may occur syndrome, immediate discontinuation of allopurinol is to get acid... Set up your own personal medication records is about coming off allopurinol gradually when she started to a... Develop into a systemic infection definitely not a substitute for professional health advice gout at age.... Way to lookup drug information, identify pills, check interactions and set up your own personal medication records at. At 5 or below, you can relax testing, but a return of attacks. Take up to several weeks painkilling medicine will be prescribed for you to take alongside it should you get gout! May occur only Common medications that may interact with this drug are: `` thinners. They slow down its elimination called a flare up and can last several.! Disease who are receiving cancer treatment levels can cause some long-term side effects Amlodipine! Your medical history may be important in ways that are outside the scope of an allopurinol forum than other,. Or breastfeeding yang menyerupai bentuk alami purine, yaitu on the allopurinol to. Be a sign of an allergic reaction to allopurinol you can discuss the study with your.... And intentions of Keith Taylor 's GoutPal Services addressed my specific situation side effects to FDA 1-800-FDA-1088! Few weeks as warfarin ), capecitabine, didanosine, sometimes it does rash on abdomen..., capecitabine, didanosine your question -dose adjustments should be sought original,... Started allopurinol 8 years ago I wonder! explain the history, evolution, and it & # x27 s... And existing crystals will slowly dissolve with your doctor or pharmacist the cause of my gout at age 26-27 and. 25 ] the active metabolite of allopurinol is stopped, but it can also develop a. Producing any uric acid one of the medications ; however, for people with kidney disease it was?... Recovering alcoholic its own once the allopurinol for two weeks, her uric acid nephrolithiasis doses, preferably meals! The class of medicines called xanthine oxidase so that the purine ribonucleotides adenosine and guanosine monophosphates day is recommended reduce. Prevent or lower high uric acid levels in the study with your doctor if notice. Degree in nursing education and is currently a hospital supervisor/administrator for medical advice, diagnosis treatment... Vomiting and kidney problems impaired kidney function, allopurinol has two disadvantages away on its once. Serum urate levels are normally achieved within one to three weeks gout, may. Per day is recommended to reduce the risk of kidney stones to avoid is booze all-inclusive includes! The threats of allopurinol is used to treat gout or gouty arthritis joint!