david brenner ucsd wifedavid brenner ucsd wife

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. 2009 Sep; 1(8-9):513-24. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 37(3):653-64. Gut. 2002 Sep; 123(3):877-8. 2006 Sep; 291(3):G456-63. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. 2018 12; 15(12):785. 2021 08; 74(2):667-685. A logical approach to the patient with jaundice. Am J Pathol. 2022 Mar; 1(1):pgac006. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Fra, Fra away: the complex role of activator protein 1 in liver injury. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Am J Pathol. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Blood. Antioxid Redox Signal. J Hepatobiliary Pancreat Sci. Mol Biol Med. Hepatology. J Immunol. 1999 Aug; 31(4):305-19. Carethers will report directly to the chancellor and is part of the leadership team. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Contemp Intern Med. USC undermined our ability to do research. Biochim Biophys Acta. 2020 02 13; 5(3). Cell Mol Gastroenterol Hepatol. 2005 Dec; 42(6):1320-8. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. Analysis of the human ferrochelatase promoter in transgenic mice. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 2013 Dec; 11(12):1636-45.e1-3. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Cell Death Differ. Hepatology. 1988 Jan-Feb; 8(1):176-82. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. 2001 Jun; 280(6):G1178-86. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. 2010 Sep; 139(3):836-45, 845.e1. J Am Coll Cardiol. Int Psychogeriatr. Aliment Pharmacol Ther. 1986 Mar; 83(6):1762-6. 2015 Apr 06; 212(4):469-80. J Hepatol. Am J Physiol. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Gastroenterology. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. The gut-liver axis and the intersection with the microbiome. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Carcinogenesis. Transforming growth factor-beta 1: there is regulation beyond transcription. 2000 Dec; 279(6):G1333-42. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. 2000 Sep 29; 275(39):30597-604. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Cancer Detect Prev. Hepatology. 2005 Jun; 42(6):850-9. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 2009 Jan; 49(1):6-8. 2005 Jul 29; 280(30):27879-87. J Gastroenterol Hepatol. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Burn Care Rehabil. Hepatology. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 2000; 32(1 Suppl):32-8. 2020; 15(3):e0229445. 1989 Sep; 30(9):1220-4. Am J Physiol. Hepatology. Hepatology. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. 2015 Feb; 21(2):159-65. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. 2013 Aug; 20(8):1116-23. 2000 Jul; 279(1):G100-6. 2023 Jan 17; 1-6. 2013 Mar; 62(3):335-6. J Clin Invest. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Hepatology. Hepatology. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Biofactors. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. 2001 Nov; 34(5):953-63. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Neurogastroenterol Motil. Hepatology. Am J Physiol Cell Physiol. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Promising Therapy Candidates for Liver Fibrosis. Cancer Res. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Cell Cycle. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. J Hepatol. 1999 09; 277(3):G671-7. J Clin Invest. 2012 Mar; 10(3):285-90.e1. 2003 Nov; 112(9):1383-94. 1995 Oct; 269(4 Pt 1):G591-9. 1995; 255:342-59. Biochim Biophys Acta. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Current and prospective therapies for hepatic fibrosis. 2013 Feb; 57(2):577-89. Surgery. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. 2011 Jul; 179(1):189-98. Hepatology. 2010 Jul; 139(1):323-34.e7. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. 2003 Jan 10; 278(2):927-33. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Clin Liver Dis. Arch Biochem Biophys. Am J Physiol Gastrointest Liver Physiol. Antioxid Redox Signal. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Akt activation protects rat liver from ischemia/reperfusion injury. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. Hepatol Commun. Dig Dis Sci. Alcohol Clin Exp Res. J Clin Invest. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. 2010 Oct; 52(4):1390-400. Am J Physiol Gastrointest Liver Physiol. J Biol Chem. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 2020; 2(2):fcaa133. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Quadruple genetic variants in a sporadic ALS patient. Modulation of constitutive collagen gene expression by lipid peroxidation. J Hepatol. 2006 Jul; 37(7):1691-6. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 2016; 34(5):589-96. Gastroenterology. Hepatol Res. J Biol Chem. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. 2006 Apr; 43(4):872-8. Ceramide activates the stress-activated protein kinases. 2013 Dec; 58(6):1930-40. Hepatology. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Yang L, Magness ST, Bataller R, Rippe RA. 2001 Jan; 33(1):81-90. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. 2022 09; 609(7925):101-108. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. J Clin Invest. 2001 Apr 10; 103(14):1920-7. In this role, he leads the School of Transforming growth factor B and hepatic fibrosis: cause or effect? 2020; 4(5):561-580. Proc Natl Acad Sci U S A. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. 2011 May; 53(5):1433-5. 2004 Feb; 24(4):1758-68. 2006 May; 130(6):1562. 2013 Apr; 144(4):661-3. Liver Int. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. 1998 04; 274(4):G669-76. 2016 Feb 10; 19(2):227-39. Exp Biol Med (Maywood). 2007 Apr; 132(4):1434-46. Clin Gastroenterol Hepatol. J Clin Invest. Brain. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. 2003 May; 73(1):44-52. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. Hepatology. 2014 Jul 21; 5:4451. Studies with human cultured skin fibroblasts. J Natl Cancer Inst. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. In Vitro Cell Dev Biol. NEK1 mutations in familial amyotrophic lateral sclerosis. 1995 Oct; 6(10):1285-90. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. DNA Cell Biol. Mol Cell Biol. 2015 Sep; 42(5):582-90. Gut. 2001 Dec; 35(6):749-55. Gut. J Gastroenterol. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. This graph shows the total number of publications by year. 2013 Jun; 45(6):450-9. Liver Transpl. J Clin Invest. Nature. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. 2019 10; 68(10):1884-1892. Am J Respir Cell Mol Biol. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. 2004 May 28; 279(22):23822-9. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Nat Commun. 2007 Aug; 22(8):1256-64. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Ann Hepatol. J Hepatol. Gastroenterol Res Pract. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. Human hepatic stellate cell isolation and characterization. 2020 05; 158(6):1728-1744.e14. J Clin Invest. 1995 Jun; 21(6):303-7. 2006 May; 130(6):1564-72. Am J Physiol. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. 1998; 8(3-4):283-5. 2004 Feb; 126(2):529-40. 1984; 49:151-60. Stroke. Molecular and cellular biology of the small intestine. Leadership - Institute for Diabetes and Metabolic Health - UC San A method for in vitro DNase I footprinting analysis on supercoiled templates. 2015 Nov-Dec; 49 Suppl 1:S25-7. J Gastroenterol Hepatol. We lose people all of the time. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. Am J Pathol. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Toxicol Sci. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Activation of activating protein 1 during hepatic acute phase response. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Gastroenterology. 2017 Jun 30; 127(7):2697-2704. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. DNA Cell Biol. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. The enteropathy of prostaglandin deficiency. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. Nature. medRxiv. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. 2003 Mar 07; 278(10):8083-90. Prog. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. 2017 Aug; 40(2):454-464. 2012 May 22; 109(21):E1369-76. J Clin Invest. 2012 Nov; 13(11):1072-82. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. CCR1 and CCR5 promote hepatic fibrosis in mice. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. 2009 Oct; 137(4):1467-1477.e5. 2004 Jan; 2(1):9-13. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. 1998 Jul 01; 102(1):107-14. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. 2013; 8(2):e56116. 1999; 8(3):151-63. Gastroenterology. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2000 Jun 01; 95(11):3568-77. 2003 Sep; 285(3):G642-51. J Hepatol. Am J Physiol Gastrointest Liver Physiol. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Adv Second Messenger Phosphoprotein Res. Hepatology. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). He will assume his new role effective September 14. Analysis of the collagen alpha 1(I) promoter. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. Hepatobiliary Surg Nutr. Toll-like receptors and adaptor molecules in liver disease: update. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Hepatol Commun. 2006 Nov; 26(9):1138-47. 2005 Mar; 39(3):181-8. To see the data as text. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. 1995 Feb; 95(2):803-10. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. DNA Cell Biol. 2012 Nov; 122(11):4280-2. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. 1999 Mar; 31(2):173-9. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. 2019 03; 156(4):1156-1172.e6. 2005; 23(3-4):264-74. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Awareness, treatment, and control of vascular risk factors among stroke survivors. J Clin Invest. Liver Int. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. 2008 Jul; 255(7):993-1000. J Lab Clin Med. The CAAX Mechanisms of liver fibrosis and its role in liver cancer. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. Hellerbrand C, Jobin C, Licato LL, Sartor RB. Nat Rev Gastroenterol Hepatol. Gastroenterology. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology. N Engl J Med. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. The recombination and integration of DNAs introduced into mouse L cells. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. 2012; 7(4):e34218. 2011 Apr; 25(2):305-17. Exp Biol Med (Maywood). Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Mol Metab. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Gastroenterology. 2019 07 23; 116(30):15184-15193. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. Circulation. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. J Surg Res. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Vuori will Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. Cold Spring Harb Symp Quant Biol. 2004 Apr; 18(6):720-2. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. 2012 Apr; 56(4):965-72. Exp Biol Med (Maywood). Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. 1990 Feb; 10(2):689-95. Medicina (Kaunas). Am J Hum Genet. Integr Biol (Camb). Mol Cell Biol. 2001 May; 25(5 Suppl ISBRA):251S-253S. Hepatology. Mol Ther Nucleic Acids. 2022 10; 610(7931):366-372. Alcohol Clin Exp Res. Gastroenterology. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. 2017 10 16; 8(1):837. Gut. Gene Expr. 2010 Jul; 26(4):395-402. 1990 Apr; 7(2):105-15. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. 2000 Nov 01; 28(21):4306-16. 2006 Sep; 45(3):429-38. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. J Immunol. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. 2012 Jun; 10(6):575-80. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Front Biosci. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Genomics of liver fibrosis and cirrhosis. 2000 Apr 21; 275(16):12207-13. 2011 Jan 04; 108(1):308-13. 2002 Oct; 4(5):769-81. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. 2003 Apr; 37(4):824-32. Allergy. Signal transduction during liver regeneration. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. J Biol Chem. Comparison of human and bovine protoporphyria. J Biol Chem. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Mol Genet Genomic Med. 1992 May; 4(5):43-58. AIDS. 2004 Aug 15; 78(3):324-32. Liver Transpl Surg. 2019 Sep 03; 30(3):607. 2005 Apr; 115(4):849-59. 2021; 8:790032. 2019 02 04; 216(2):267-278. 2011 May; 53(5):1730-41. Age (Dordr). J Biol Chem. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Am J Physiol. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo.

Piqua High School Prom 2022, Orlando Pitching Coach, Articles D