Zostavax will no longer be sold in the United States starting July 1, 2020. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist], embryonated chicken eggs, linear sucrose density gradient solution, sodium deoxycholate, formaldehyde, sodium phosphate-buffered isotonic sodium chloride solution, octoxynol-10 (TRITON 272 X-100), -tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, phosphate buffered saline, thimerosal, egg proteins (ovalbumin), polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate, allantoic cavity of embryonated hens eggs, kanamycin, neomycin sulphate, formaldehyde, cetyltrimethylammonium bromide (CTAB), thimerosal, egg proteins, formaldehyde, polysorbate 80, CTAB, neomycin, kanamycin, barium, Manufacturer: Sanofi Pasteur, Inc (for Fluzone High-Dose and Fluzone Intradermal only), Fluzone Intradermal Package Insert (2017-2018), Fluzone: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 214 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose: embryonated chicken eggs, formaldehyde, inear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone High-Dose: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Intradermal: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, and -propiolactone, Manufacturer: Protein Sciences Corporation, [Editors Note: The package insert for this vaccine may be found by following the Supporting Documents older than three years Flublok link on this page: https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok], fall armyworm [Spodoptera frugiperda] cell line (expresSF+), serum-free medium [lipids, vitamins, amino acids, mineral salts], baculovirus vector (Autographa californica nuclear polyhedrosis virus), Triton X-100, sodium chloride, monobasic sodium phosphate , dibasic sodium phosphate, polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Flublok Quadrivalent Package Insert (Mar. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Tell your vaccination provider if the person getting the vaccine: In some cases, your health care provider may decide to postpone shingles vaccination until a future visit. Ask your health care provider for guidance. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Safety, tolerability, and immunogenicity of zoster vaccine in subjects with a history of herpes zoster. 2015:372:2149-2150 [Link: ]. Shingrix is now covered by most health insurance plans. 2012 Jan 20;30(5):904-10. Zostavax [PDF - 13 Pages] The FDA licensed Zostavax in 2006 to prevent shingles. ], ProCon.org, "Vaccine Ingredients and Manufacturer Information,", ProCon.org, "Vaccine Ingredients and Manufacturer Information. What are the ingredients in the Shingles vaccines? Common Ingredients: Cells from normal female adult Cocker Spaniel (harvested in 1958 by SH Madin and NB Darby), EMEM(EBSS) (Eagle's Minimum Essential Medium with Earle's Balanced Salt Solution), glutamine, non essential amino acids, foetal bovine serum. in adults aged 18 years and older who are or will be at increased risk of. Fenton medium containing a bovine extract, Latham medium derived from bovine casein, formaldehyde, Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide, VERO cells, calf serum and lactalbumin hydrolysate, filamentous hemagglutinin (FHA), pertactin (69 kiloDalton outer membrane protein), aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, Quadracel version 1 Package Insert (Feb, 2021), Quadracel version 2 Package Insert (Dec. 2019), version 1: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, aluminum phosphate, MRC-5 cells, CMRL (Connaught Medical Research Laboratories) 1969 medium supplemented with calf serum, Medium 199 without calf serum, 2-phenoxyethanol, water, version 2: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, Vero cells, Iscoves medium, calf serum, M199 medium without calf serum, 2-phenoxyethanol, water, version 1: filamentous hemagglutinin(FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, 2-phenoxyethanol, water, polysorbate 80, formaldehyde, glutaraldehyde, bovine serum albumin, 2-phenoxyethanol, neomycin, polymyxin B sulfate, version 2: filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, polysorbate 80, 2-phenoxyethanol, formaldehyde, glutaraldehyde, bovine serum albumin, streptomycin sulphate, neomycin and polymyxin B sulphate, 11. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Safety of herpes zoster vaccine in the shingles prevention study: A randomized trial. Shingles, or herpes zoster, is a painful skin rash that develops on one side of the face or body. Hib Vaccine(haemophilus influenzae type B), Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate), amorphous aluminum hydroxyphosphate sulfate (previously referred to as aluminum hydroxide), sodium chloride, Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate), semi-synthetic medium, ammonium sulfate, Mueller and Miller medium, milk-derived raw materials (casein derivatives), saline diluent, purified capsular polysaccharide, synthetic medium, semi-synthetic medium, formaldehyde, lactose, sterile saline solution, purified capsular polysaccharide, lactose, formaldehyde, aluminum hydroxide, amino acid supplement, phosphate-buffered saline solution, polysorbate 20, MRC-5 cellular proteins, formalin, neomycin sulfate, MRC-5 diploid fibroblasts, amorphous aluminum hydroxyphosphate sulfate, nonviral protein, DNA, bovine albumin, formaldehyde, neomycin, amorphous aluminum hydroxyphosphate sulfate, sodium borate, sodium chloride, 16. Redness and swelling can also happen at the site of the injection. The efficacy of two doses of Shingrix for the prevention of postherpetic neuralgia (PHN) was high: 91.2% in adults aged 50 years and older, and 88.8% in adults aged 70 years and older. 5 Additionally, Shingrix is not egg-based, and it does not contain thimerosal , a mercury-containing preservative. 2014 Aug 22; 63(33):729-731. Tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea are common after recombinant shingles vaccine. All information these cookies collect is aggregated and therefore anonymous. Other effects include: Many people who get the vaccine have muscle aches, headaches, or feel tired. These cookies may also be used for advertising purposes by these third parties. You can review and change the way we collect information below. Afluria Quadrivalent Southern Hemisphere: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. Centers for Disease Control and Prevention. Zostavax is made from the whole but . Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia(PHN), the most common complication from shingles. If they have a reaction to the first dose of Shingrix, it does not necessarily mean they will have a reaction to the second dose. filamentous hemagglutinin (FHA), pertactin (69 kiloDalton outer membrane protein), aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80). This long-lasting pain is called postherpetic neuralgia (PHN), and it is the most common complication of shingles. Cookies used to make website functionality more relevant to you. DTaP (diphtheria, tetanus, & pertussis), 9. Also, about 1 out of 10 reported grade 3 systemic reactions such as myalgia, fatigue, headache, shivering, fever, and gastrointestinal illness. Shingrix is a new adjuvanted, non-live recombinant shingles vaccine. About 1 out of 6 people had symptoms severe enough to prevent them from doing regular activities. Your reaction to each dose may be different; just because you have a reaction to the first dose does not mean that you will have a reaction to the second. ], sodium chloride, lipids ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide, 1,2-distearoyl-sn-glycero-3-phosphocholine, cholesterol), potassium chloride, monobasic potassium phosphate, dibasic sodium phosphate dihydrate, sucrose, Vero cells (African Green Monkey kidney), stabilizer solution, sodium chloride, essential amino acids (including L-phenylalanine), non-essential amino acids, L-arginine hydrochloride, sucrose, D-trehalose dihydrate, D-sorbitol, trometamol, urea, aluminum phosphate, isotonic sodium chloride solution, formalin, tryptic digest of casein, cystine, maltose, uracil, inorganic salts, vitamins, 8. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Shingrix vs. Zostavax Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. Before you administer Shingrix, CDC recommends counseling your patients about the common reactions to the vaccine. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. ACIP will review evidence for Shingrix in immunocompromised people as it becomes available. However, there are no data or theoretical concerns to indicate that Shingrix would be less safe or less effective when given at an interval shorter than 5 years following Zostavax. We take your privacy seriously. Your risk of getting shingles and PHN increases as you get older. Report clinically important adverse events that occur after vaccination, even if you are not sure whether the vaccine caused the adverse event, to the Vaccine Adverse Events Reporting System (vaers.hhs.gov). In eight clinical trials of more than 10,000 immunocompetent participants 50 years or older, grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common after patients received Shingrix. It also causes chickenpox. . If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Some people who have or will have a weakened immune system can get the second dose 1 to 2 months after the first dose. A single dose after reconstitution is 0.5 mL. MMR Vaccine(measles, mumps, & rubella), Measles, Mumps, and Rubella Virus Vaccine, Live, chick embryo cell culture; WI-38 human diploid lung fibroblasts, recombinant human serum albumin, fetal bovine serum, sorbitol, sucrose, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, neomycin, other buffer and media ingredients, 24. Are there any blood fractions, cells, or anything to do with blood products used in the shingles vaccine? 2011 Nov;7(11):1130-6. Two doses of Shingrix are more than 90% effective at preventing shingles. 80% of the proteins in cow's milk are casein. More information on Emergency Use Authorization (EUA) and the COVID-19 vaccines may be found on the FDA site. Recombinant shingles vaccine provides strong protection against shingles. Who should get vaccinated against shingles Shingrix provides strong protection against shingles and long-term pain from the disease. These same fetal cells obtained from the early 1960s have continued to grow in the laboratory and are used to make . You need to come back in 2 to 6 months for your second dose. Clin Infect Dis. Controversial products used to make vaccines include but are not limited to: African Green Monkey (Vero) cells, aluminum, cow products, Cocker Spaniel cells, formaldehyde, human fetal lung tissue cells, insect products, and mouse brains. Reporting is encouraged for any clinically significant adverse event even if it is uncertain whether the vaccine caused the event. About 1 out of every 3 people in the United States will develop shingles in their lifetime. People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles vaccine. People who have had shingles in the past and people who have received varicella (chickenpox) vaccine are recommended to get recombinant shingles vaccine. CDC recommends two doses of recombinant zoster vaccine (RZV, Shingrix) to prevent shingles and related complications in adults 50 years and older. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. There is no live virus in recombinant shingles vaccine. Though not listed, each vaccine contains strains of the virus being vaccinated against. Severe allergic reactions to Shingrix are very rare. Cookies used to make website functionality more relevant to you. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. The shingles vaccine does not contain thimerosal (a preservative containing mercury). You can review and change the way we collect information below. You can protect yourself against shingles. Tseng HF, Liu A, Sy L, Marcy SM, Fireman B, et al. You will be subject to the destination website's privacy policy when you follow the link. Thank you for taking the time to confirm your preferences. You can review and change the way we collect information below. 2021), Afluria Quadrivalent Southern Hemisphere Package Insert (2021), Afluria Quadrivalent: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. MMWR Recomm Rep. 2008 Jun 6;57(RR-5):1-30. More information about contraindications and precautions. You may have heard you can pass the virus to others if you get the Zostavax shingles vaccine. What to tell patients about Shingrix benefits: What to tell patients about Shingrix side effects: We take your privacy seriously. Information on how to submit a report to VAERS is available at VAERS website, or by calling 1-800-822-7967. All rights reserved. Vermeulen JN, Lange JM, Tyring SK, Peters PH, Nunez M, et al. Cunningham AL, Lal H, Kovac M, Chlibek R, Hwang SJ, Diez-Domingo J, et al. ZOSTAVAX contains a weakened chickenpox virus (varicella-zoster virus). 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