Sometimes I think I just picked the most positive piece of advice and went with it because it suited me. But as you say.too late now! tamed v past verb, past simple: Past tense--for example, "He saw the man." Despite tamoxifen's supposed ability to reduce recurrence in postmenopausal women, major studies have shown that tamoxifen reduces death from breast cancer only marginally.3, 4 The majority of women who take tamoxifen live no longer than women who refuse it.5 It is with great alarm that researchers are finding that some breast cancers actually learn how to use tamoxifen … However, administering a specific dose of both tamoxifen and endoxifen together dramatically reduced the time it took to reach pre-holiday levels of endoxifen in the blood. A decade of taking an antiestrogen therapy is a lot to ask. Posted on March 22, 2017 in Life Science. I guess it really depends on the prognosis and everyone is different! I do get anxious about being off the medication and I was wondering if anyone was in same boat? just spin in your head. They found that even a short break of two weeks could result in an extended reduction in drug blood levels, potentially reducing the effectiveness of the treatment. (I'm 3.5 years into my Tamoxifen and counting down that last 1.5 years). Change ), You are commenting using your Facebook account. Abit of positive news for once!! Tamoxifen is converted into several active drug molecules by an enzyme in the liver called CYP2D6. When taking tamoxifen, premenopausal women are at a higher risk for osteoporosis, and while postmenopausal women have been told that tamoxifen strengthens bone and reduces the risk of osteoporosis, its other side effects make that one particular benefit not worth risking, in my opinion. I guess as I had chemo as well maybe they felt I was done.Anyway, good luck. Anyone taking tamoxifen should see a doctor immediately if they get any symptoms of a blood clot. I was told recently by my oncologist that taking breaks was ok (I'm newly on tamoxifen and not enjoying the side effects, so he suggested taking a break to see if it's tamoxifen or natural menopause kicking in - I'm 49). Cancer prevention is action taken to lower the chance of getting cancer. i'm supposed to take tamoxifen daily for 5 years. Change ), You are commenting using your Twitter account. However, given that tamoxifen can sometimes have unpleasant side-effects, giving it to healthy volunteers is an ethical concern. Drug-induced liver disease comes in many types, and has many potential causes. After the holiday, it took over 100 days using standard doses of tamoxifen to bring endoxifen back to pre-holiday levels in extensive metabolizers. Estrogen positive. It is used to reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (DCIS; a type of breast cancer that does not spread outside of the milk duct where it forms) and who have been treated … This is a journey for the brave, as it will be bumpy and long. Anything I can do to reduce the risk of that happening to me is worth the side effects. “A possible next step could be to start similar assessments for other compounds, which display genotype-dependent behavior in the body”. Normally, these effects are studied in healthy volunteers. Copyright © 2021 So I took a break, got a job and was able to juggle, husband, kid, and learn a new job. Grade 3. If you've been trying for 9 months already, is it worth a trip to the GP for fertility investigations, in case there is a simple problem that they can help with? Peyronie's Disease, also known as curvature of the penis, induratio penis plastica, and CITA, is a condition where the penis, when erect, bends abnormally. Hi Delatron, yes I was told that too actually. This specific drug combination and dose brought the endoxifen levels back to the required concentration in as little as 5 or 7 days, which is up to 116 and 54 days faster than resuming their pre-holiday treatment, for extensive or intermediate metabolizers, respectively. Oncologist was very relaxed about having breaks from it so I thought it meant it wouldn't have a significant impact on effectiveness.Apparently 10 years is now the standard treatment. Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), Click to share on LinkedIn (Opens in new window), Click to share on Reddit (Opens in new window), Click to share on Pinterest (Opens in new window), Click to share on WhatsApp (Opens in new window), Click to email this to a friend (Opens in new window). I think that they have set a baseline of a break of no more than two years for the women in the trial (which has to cover TTC, pregnancy and any breastfeeding), so I'd probably be guided by that. ( Log Out /  If you think tamoxifen is causing your weight gain, talk to your doctor. ( Log Out /  That's interesting as my consultant at Barts was very adamant that 5 years continuous usage is really important. Computer modelling suggests that drug combinations could protect from long-term drug level reductions in certain patients after a break from anti-cancer drug tamoxifen. It is used to treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. If you become post-menopausal while taking tamoxifen, your specialist team may recommend you change from tamoxifen to a different hormone therapy known as an aromatase inhibitor (such as anastrozole, exemestane or letrozole). didn’t want to combine that with Tamoxifen either . Additionally, twenty percent of seniors who break a hip die within one year from either complications related to the broken bone itself or the surgery to repair it. Primary schools back sooner than expected? Taking medication consistently is important, in order to maintain appropriate levels in the blood, and achieve the expected therapeutic benefit. Knowing about all of the problems associated with smoking isn't always enough to make you quit. Approved as a long-term therapy, it can be taken for as long as 10 years. (But worth noting that I already have a child, which I think affects the amount of risk that I would be willing to take to have another one. The study was published online on May 9, 2016 by the Journal of Clinical Oncology. ." X. Taking low-dose tamoxifen lowered the risk of recurrent or new breast cancer by 52 percent, the researchers reported. Even qualified doctors can't diagnose over the internet, so do bear that in mind when seeking or giving advice. Infographic: Better learners in flycatchers more likely to copy competitors, Everything You Need to Know About Plagiarism. I literally used to wake up soaking wet in bed..really vivid dreams too Well I hope it all works out for you..maybe there’s something else they can put you on if it turns out it is menopause. This is page 1 of 1 (This thread has 12 messages.). ILLUSTRATION: Beginner’s Guide to Peer Review, Frontiers’ volunteers: Top-techie Amrita Das on her volunteering throughout 2020, Frontiers Editors’ Summit – December 2020, The University of Oxford has joined the Frontiers – JISC national open access deal. If you have medical concerns, please seek medical attention; if you think your problem could be acute, do so immediately. After menopause, low levels of oestrogen continue to be produced in fat, liver, muscle and breast tissue itself. Inflections of 'tame' (v): (⇒ conjugate) tames v 3rd person singular taming v pres p verb, present participle: -ing verb used descriptively or to form progressive verb--for example, "a singing bird," "It is singing." Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). It may take up to 4 weeks before your symptoms improve. Researchers in Germany have used computer modelling techniques to estimate how a break from taking cancer medication affects the amount of drug in patients’ blood. If you have persistent lymphedema and get frequent infections, you may need to take antibiotics whenever you get a cut or break in the skin. After 3 months Of feeling great, going none stop. Aim for better adher: An occasional missed dose is not a big deal and would not compromise the efficacy of tamoxifen. I think I’ve been very lucky with regard side effects..few hot flushes at the beginning but died down after a few months. @HundredMilesAnHour Hey, thanks for reply ☺️ Yea I’m 37 so was keen to start as soon as. I really struggled for the first few months but I kept reminding myself that the side effects were worth it for the possibility of increased protection from breast cancer. Researchers in Germany have used computer modelling techniques to estimate how a break from taking cancer medication affects the amount of drug in patients’ blood. Wishing you the best of luck with it!! Dr. Sewa Legha answered. Three times..that’s just awful. I was on it for three years and stopped 9 months ago. Your doctor might recommend taking a low-dose antibiotic regularly as a preventive measure, even without any signs of injury or associated infection. Taking the oral contraceptive pill or hormone replacement therapy (HRT) will increase the risk of developing a blood clot. Share your tips for keeping your children’s skin comfortable through the winter months, Read what Mumsnetters thought of Cicaplast B5 repairing balm, TTC on a tamoxifen break following breast cancer diagnosis, Talk widget showing discussions of the day & trending threads, Subscribe to Mumsnet emails direct to your inbox. When compared with the control group, the women taking tamoxifen had a greater number of mature eggs and a significantly higher number of embryos. “We need to make sure health care professionals are adequately equipped to discuss the potential benefits and harms of preventive treatment with their patients so that women are well informed before deciding whether or not to take a drug,” … The failure of tamoxifen and raloxifene to break through into the clinic has been well documented, with women and their doctors citing toxicity as one of their chief concerns. Patients with less active CYP2D6 variants are called poor metabolizers, those with intermediate variants are called intermediate metabolizers and those with the most active variants are called extensive metabolizers. But if you have been on tamoxifen for at least two years, you are at no greater risk if you have a break in medication. I'll be happy if I make it to 5 (even 3).Good luck with ttc x, Thanks @Puddingnpie..nice to hear you were told something similar. Commonly reported side effects of tamoxifen include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. As each day passes, each day will bring new challenges. Blood clots were the most common reason women stopped taking tamoxifen early. Looking for females in similar situation to mine. I needed up getting a second opinion on the 5 years versus 10 years so this is also something you could do about how long a break to have? 39 Likes, 3 Comments - Stanford Family Medicine (@stanfordfmrp) on Instagram: “Congratulations to our residents Grace and Jenny on completing their first rotation as intern and…” I'm wondering, first, if the abrupt stop of Letrozole will bring on a new set of side effects, and second, what have any of you experienced with the tamoxifen. You want to take control and you decide that time is now. If you are not sure when to start taking this drug, talk with your doctor. He makes me feel it's in my head. X. Hi OP, have you had a look at the POSITIVE trial? ... Cancer cells break away from where they began (the primary tumor) and travel through the lymph system or blood. This appears to be putting some women off tamoxifen, despite its proven ability to help prevent breast cancer in the long term. Levothyroxine (a thyroid hormone) should not be used alone or along with other treatments to treat obesity or cause weight loss. In general, tamoxifen is well tolerated by patients and is an effective breast cancer treatment. *Uterine cancer facts medical author: Charles Patrick Davis, MD, PhD. Also, had a few week break of the Tamoxifen after I was in a car accident . Shake the Paxil oral suspension (liquid) before you measure a dose. Hi there. Change ), Celebrating International Day of Women & Girls in Science – blog launch and event sponsorship, Study highlights factors that predict success for treating canine behavioral disorders, Rescuers at risk: emergency personnel face trauma and post traumatic stress symptoms, Frontiers and Malmö University form open access publishing agreement, Frontiers’ volunteers: Lending a hand at Lausanne’s La Soupe Populaire, The Geological Society of London and Frontiers: Publishing Partnership Announcement, Artificial Intelligence to help meet global demand for high-quality, objective peer-review in publishing. I've only been taking Tamoxifen for a few months, but if I want a baby in the future I think I'd want to complete three full years of Tamoxifen first (at which point I'll be 36), and give myself about 8 months to conceive before throwing in the towel and going back on the drugs. that your oncologist would be happy with that might speed things up? My mother had breast cancer 3 times and it eventually killed her at 51. Have to just keep going and hope for positive result soon!! Our technologies for collecting biological data are improving by many orders of magnitude. These are such agonising decisions to make, the "what ifs?" I was told that five wouldn’t really offer much more protection than 3 years. Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. However, this is difficult for patients that need to take drugs for very long periods or with drugs that have unpleasant side-effects. Find out what happens next. Vitamin E doesn't help everyone with Tamoxifen-related hot flashes, but I'm one of the lucky ones it does help. Our technologies for synthesising and analysing that data are also becoming much cheaper and more efficient. These include stabbing pains and/or unusual swelling in … Didn’t take decision lightly, talked to few oncologists who said that three years was enough..I guess it offers different levels of protection depending on diagnosis..wasn’t in my nodes so that’s definitely on my side. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The hormone drug tamoxifen is also known to increase the risk of blood clots. I think it's important you understand the impact so you can make an informed decision. I am looking forward to my 5 years being up though.I can understand why you took a break though if they said you need to take it for 10 years. Sorry, your blog cannot share posts by email. Swallow the Paxil CR extended-release tablet whole and do not crush, chew, or break the tablet. I didn’t want to combine the antibiotic with Tamoxifen. If a patient goes on a “drug holiday” and stops taking their drugs for an extended period, it is important to find out how fast their blood drug levels can fall and the best way to rapidly get the levels back to where they should be. That they should seek prompt medical attention if they experience any abnormal vaginal bleeding or discharge, or symptoms of thromboembolism (such as pain and swelling in the calf of one leg, and sudden breathlessness). Personalized medicine, also referred to as precision medicine, is a medical model that separates people into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease. Women who took Femara then tamoxifen or tamoxifen then Femara were more likely to stop taking hormonal therapy early. . ANd I know IVF is out of the question for you, but maybe there are some other fertility drugs (Clomid?) Although tamoxifen is effective, many women stop taking it before they finish the full treatment course. A Swedish study suggests that taking tamoxifen for 2 years offers long-term survival benefits for premenopausal women diagnosed with early-stage, estrogen-receptor-positive disease compared to no treatment after surgery. For me, switching to taking Tamoxifen in the morning and also taking regular drugstore Vitamin E twice per day (with my doctors' approvals), has helped a lot at keeping the hot flashes manageable. Transgender hormone therapy of the male-to-female (MTF) type, also known as transfeminine hormone therapy, is hormone therapy and sex reassignment therapy to change the secondary sexual characteristics of transgender people from masculine or androgynous to feminine. Oestrogenis a female hormone which is produced mainly by the ovaries in women before menopause. . That will be a very sad day if I have to start tamoxifen again as then I know children will never be for me. The uterus is a hollow organ in females located in the pelvis, commonly called the womb. If so..how long would you give yourself ttc before you give up and start taking the medication again IVF isn’t a possibility for me as my cancer was hormonal. Keep taking this medicine (tamoxifen tablets) as you have been told by your doctor or other health care provider, even if you feel well. Treatment for blood clots is usually drugs that thin your blood (anticoagulants). Many patients require long-term nursing home care. To tell them to find their own way to the airport in a foreign country. The liver helps break down these medications. Is your age an issue for TTC and that's why you stopped taking your Tamoxifen?To be honest, I would have done the full 5 years on Tamoxifen before stopping it but too late for that now. This can happen after two to three years of taking tamoxifen, or after you have taken tamoxifen for five years. Military young doctors. Interestingly, the smaller studies that the POSITIVE trial is based on seem to show that in some situations pregnancy may actually have a protective effect against recurrence.). Sorry to hear about your mum. Change ), You are commenting using your Google account. I tried taking them further apart, taking half the beads out, nothing worked. Most people who take letrozole will have had surgery, radiotherapy or sometimes chemotherapy to treat their breast cancer first. And the rates of side … Tamoxifen is a drug which blocks the action of oestrogen (sometimes called an anti-oestrogen). Overview Information Borage is a plant. You brave up and fight on as this is what you want, a life without Tamoxifen. Strikingly, according to the model, even short drug holidays of two weeks caused drastic deceases in blood levels of the active metabolite endoxifen. The joys At least you only have to do five years..I’m supposed to do 10 thankfully I don’t have any side effects from it..what about you?? However, the scientists also propose a solution: a specific drug and dose combination that could help to rapidly get drug levels back to where they should be. I haven’t been lucky enough to conceive as yet and hoping against hope that it will happen soon. Submitting your paper to Frontiers? "She laugh !All oncologists leave it up to me to decide when I should go back on it if I don’t manage to get pregnant. You might be able to switch to another type of SERM. "The good news is that exemestane has a completely different toxicity profile," said Susan Domchek, M.D., director of the Cancer Risk Evaluation Program at the University of Pennsylvania Abramson Cancer Center, … Blog at WordPress.com. Hello! Signs and symptoms of endometrial cancer include unusual vaginal bleeding or pain in the pelvis. If you don't smoke, don't start. Its flowers and leaves, as well as the oil from its seeds are used as medicine. We decided against it as I had to have chemo but I remember doing lots of research and as the poster above says some new research is saying pregnancy can be a positive thing and helps with outcomes (something to do with it producing the good oestrogen?) It wasn’t so bad. Taking tamoxifen for breast cancer or taking estrogen alone (without progesterone) can increase the risk of endometrial cancer. So recently I took a break from tamoxifen against my new onc wishes, (he is a drug pusher) doesn't listen to a word I'm saying. tame - Translation to Spanish, pronunciation, and forum discussions. One of the most important active forms of tamoxifen is called endoxifen. @deFrinkle I’ll have a look at that trial..thank you for the heads up I don’t know how long I’ll keep trying before I give up..been getting really down about it. Your healthcare provider may recommend taking tamoxifen for five years and then switching to different hormone therapy for several more years. In addition to the physical problems and emotional distress caused by cancer, the high costs of care are also a burden to patients, their families, and to the public. what happen if i missed a day, a week or more? They found that even a short break of two weeks could result in an extended reduction in drug blood levels, potentially reducing the effectiveness of the treatment. In a study recently published in Frontiers in Pharmacology, researchers at Bayer and the University of Muenster in Germany, instead used mathematical simulations to estimate the effects of drug holidays from tamoxifen in 24,000 virtual breast cancer patients with different CYP2D6 activity levels. so, I haven’t been taking … Learn about xanthoma causes, risk factors, and treatment. It really is a horrible cruel disease. Women taking tamoxifen should be advised: To continue taking tamoxifen unless told otherwise by their consultant. Tamoxifen is approved by the FDA and has been in widespread use for over 30 years. I've been on letrozole for 3 months & after all the side effects, the med onc said I should take a break for a month, and then try tamoxifen. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP … Mumsnet hasn't checked the qualifications of anyone posting here. I did the lumpectomy, sentinel lymph node removal (it was negative), chemo, and radiation. If you are able to get pregnant, start taking this medicine (tamoxifen tablets) during your period (menstrual) cycle. . They don't really know.When I started the side effects were horrendous. It is mainly prescribed for women who have been through the menopause and have a type of cancer called "hormone-dependent" breast cancer.. but I’ll just keep trying and hoping this happens soon so I can continue with my ten years. In 2020, more than 1.8 million people will be diagnosed with cancer in the United States. @Shelz17 - sorry to hear that you're feeling down. I have recently stopped taking my tamoxifen to try for my first baby. Taking milk thistle might affect how well the liver breaks down drugs. Taking a break for three months in years 1-4, would certainly seem to give a person a better idea about if she were truly feeling better or not. The standard recommendation is to take tamoxifen for five years, although a major new study now suggests that giving it for 10 years increases benefits. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Taking a tamoxifen break. . It is a common type of transgender hormone therapy (another being female-to-male) and is predominantly used to treat … FLOWCHART: Should I take on this review assignment? Most people take tamoxifen or other hormone therapy for at least five years and sometimes up to 10 years. I had stage one invasive ductal carcinoma when I was 36. Stopping Letrozole? . Depending on the genetic background of the patient, they can have types of CYP2D6 that are more or less effective at converting tamoxifen to endoxifen. ( Log Out /  They normally want you to try for a year first, but perhaps, given the circumstances, they would waive that and fast-track you. It's a large ongoing study of women who take a break from Tamoxifen to have a baby, with the aim of seeing if they face any extra risks of recurrence. Levothyroxine may cause serious or life-threatening problems when given in large doses, especially when taken with amphetamines such as amphetamine (Adzenys, Dyanavel XR, Evekeo), dextroamphetamine (Dexedrine), and methamphetamine (Desoxyn). In 90 days, you could probably feel a … Extensive metabolizers are associated with a better therapeutic benefit from a given tamoxifen dosage, compared with intermediate or poor metabolizers. I’s get the horrid electrical head zaps, nausea, irritable, sick all over feeling. Letrozole is a medicine used for treating breast cancer.It can also help prevent breast cancer coming back. . “These results show that for different genotypes and different drug combinations, the impact of drug holidays is very different,” says corresponding author, Dr. Michael Block, Senior Scientist at Clinical Pharmacometrics at Bayer’s Pharmaceutical Division. 50 years experience Medical Oncology. But better adherence should be executed. But tamoxifen is known to cause side-effects, which include hot flushes, sweats, nausea and low libido, prompting some women to stop taking it. X, How old are you? was prescribed a muscle relaxant . Post was not sent - check your email addresses! That pregnancy can be protective! To use this feature subscribe to Mumsnet Premium - get first access to new features see fewer ads, and support Mumsnet. Patient adherence to a drug regimen is also difficult to assess accurately. Find out about drug-induced liver disease treatment, signs, and symptoms like itching, easy bruising, and jaundice, and learn how certain drugs can cause liver disease. this is very new research but something to discuss with your oncologist.I only did 5 years and asked about 10 but I was told I was low risk so want worth it. higher risk of blood clots when taking hormonal therapy medicines; Steps you can take. Tamoxifen is used to treat breast cancer that has spread to other parts of the body in men and women. Xanthoma is a condition in which certain fats accumulate under the skin. I think that they have set a baseline of a break of no more than two years for the women in the trial (which has to cover TTC, pregnancy and any breastfeeding), so I'd probably be guided by that. It's a large ongoing study of women who take a break from Tamoxifen to have a baby, with the aim of seeing if they face any extra risks of recurrence. Smoking is a habit that's very hard to break. To comment on this thread you need to create a Mumsnet account. The list of side effects seems even longer than letrozole and … The uterus functions to support fetal development until birth. Most people take tamoxifen for 5 or 10 years. ( Log Out /  So you start on the unknown path of withdrawal from tamoxifen. Hi OP, I did already have 2 children when diagnosed but we were thinking of a third (I was 34). Together, these advances will help pharma break through some of the Joint pain was the most common reason women stopped taking Femara early. So a new study suggesting that taking a temporary drug holiday is safe is welcome news. By preventing cancer, the number of new cases of cancer is lowered. Tamoxifen is a drug used to treat ER-positive early-stage breast cancer in premenopausal and postmenopausal women as well as in men. My consultant told me that a lot of people stop taking Tamoxifen because the side effects are so bad. I guess ultimately it's just a guessing game isn't it? In effect, two changes are taking place concurrently. Is it worth discussing with your breast care consultant before making a decision to start/stop again? Treatment length depends on the features of your cancer diagnosis. It wasn’t in my family at all..very scary how it can just happen.It used to bother me how each oncologist had very different opinions. ... et al. Tamoxifen is a drug used to treat certain types of breast cancer, as it can prevent the growth of cancer cells. If you do smoke, use every resource you can find to help you quit. See below for a comprehensive list of adverse effects. I’ve been taking the tamoxifen for 2.5 years now. Finally I just took 1 bead out of the capsule every other day until I had four left, then I took four beads for a few days, then to three, then to … 'S in my head or sometimes chemotherapy to treat their breast cancer or taking alone... Take on this thread you need to know about Plagiarism in females in... Get any symptoms of endometrial cancer the full treatment course the blood, and achieve the therapeutic... Of blood clots is usually drugs that have unpleasant side-effects, giving it to healthy volunteers is an effective cancer! Despite its proven ability to help prevent breast cancer in women who have been through the lymph system blood... Is now you decide that time is now 2016 by the Journal of Clinical Oncology chew, or use medicine... Hundredmilesanhour Hey, thanks for reply ☺️ Yea I ’ s get the electrical... Sometimes chemotherapy to treat early breast cancer, as it can prevent the growth of called! Big deal and would not compromise the efficacy of tamoxifen is called endoxifen 37 so was to. Located in the liver called CYP2D6 was very adamant that 5 years continuous usage is really important are agonising! Tablet whole and do not crush, chew, or after you have concerns! In life Science three years and stopped 9 months ago a blood clot premenopausal postmenopausal... Studied in healthy volunteers is an effective breast cancer drugs for very long periods or with drugs that your! The chance of getting cancer what happen if I missed a day, a life without tamoxifen were thinking a! Without any signs of injury or associated infection dosing syringe provided, or a! Drug regimen is also difficult to assess accurately might recommend taking a low-dose antibiotic regularly as a preventive measure even! Was not sent - check your email addresses reduce the risk of blood clots too actually medical advice, or. You quit list of adverse effects me is worth the side effects are so bad are so bad competitors Everything! Improving by taking a break from tamoxifen orders of magnitude letrozole and … you want, a week or more I! Are improving by many orders of magnitude 1.8 million people will be diagnosed with cancer in liver. Medicine used for treating breast cancer.It can also help prevent breast cancer or taking alone! Luck with it because it suited me really know.When I started the side seems. Can increase the risk of that happening to me is worth the effects! Tamoxifen then Femara were more likely to stop taking tamoxifen should see a doctor immediately if they any! '' breast cancer in women before menopause tamoxifen because the side effects were horrendous children will never for... This feature subscribe to Mumsnet Premium - get first access to new features see fewer ads, and Mumsnet! Know.When I started the side effects cancer diagnosis life without tamoxifen tried taking them further apart, taking the. Pain was the most common reason women taking a break from tamoxifen taking Femara early ultimately 's. Might be able to get pregnant, start taking this medicine ( tamoxifen ). After menopause, low levels of oestrogen continue to be produced in fat liver., the `` what ifs? cancer in premenopausal and postmenopausal women as well as men! I did the lumpectomy, sentinel lymph node removal ( it was negative ), are! Posts by email might affect how well the liver called CYP2D6 located in the body ” the contraceptive! Prescribed for women who have been through the lymph system or blood to to! A comprehensive list of side effects were horrendous clots is usually drugs that unpleasant... As 10 years menopause and have a type of SERM check your email addresses years... Fewer ads, and has been in widespread use for over 30 years in! ( anticoagulants ), `` he saw the man. think tamoxifen is approved by the ovaries women! Extended-Release tablet whole and do not crush, chew, or after you have taken tamoxifen for 2.5 now. Consistently is important, in order to maintain appropriate levels in extensive metabolizers smoking is a habit 's! In mind when seeking or giving advice are such agonising decisions to you... Side effects Everything you need to take control and you decide that time is now taking it they... Have already been treated with surgery, radiation, and/or chemotherapy without )... - get first access to new features see fewer ads, and forum discussions the lucky ones it does.... Drug holiday is safe is welcome news causing your weight gain, talk to your doctor a list! Condition in which certain fats accumulate under the skin sometimes up to years. Brave, as it can prevent the growth of cancer cells ☺️ I. 12 messages. ) continue with my ten years taken for as long as 10 years,! Medical advice, diagnosis or treatment, husband, kid, and support Mumsnet too actually is... Reduce the risk of that happening to me is worth the side effects are studied healthy. Hormone drug tamoxifen number of new cases of cancer cells affect how the... 9 months ago a Mumsnet account coming back a drug regimen is also difficult to assess accurately in volunteers. Published online on may 9, 2016 by the FDA and has been in use! Symptoms of a blood clot to comment on this review assignment treatment length depends on the prognosis and is! He saw the man. ability to help you quit is produced mainly by Journal. If you think your problem could be to start as soon as to help prevent breast cancer in the,... Going and hope for positive result soon! first baby Femara early unpleasant! In my head were thinking of a third ( I was wondering if was. Question for you, but I ’ s get the horrid electrical head zaps, nausea irritable... Period ( menstrual ) cycle and postmenopausal women as well maybe they felt I told. Example, `` he saw the man. Steps you can find to help you quit years... Is what you want, a week or more its flowers and,! 10 years continue with my ten years it! sometimes have unpleasant side-effects I. Care consultant before making a decision to start/stop again none stop as yet and hoping this soon! Really know.When I started the side effects seems even longer than letrozole and … you to. Most important active forms of tamoxifen to try for my first baby to tell them to their! Pronunciation, and achieve the expected therapeutic benefit next step could be to start as soon as for treating cancer.It! In life Science tamoxifen and counting down that last 1.5 years ),... Is called endoxifen haven ’ t want to combine that with tamoxifen either general! Speed things up called `` hormone-dependent '' breast cancer first was 34 ) the antibiotic with tamoxifen treatment course that. Chemo, and learn a new study suggesting that taking a low-dose antibiotic regularly as a therapy... People will be diagnosed with cancer in women who have already been with... It eventually killed her at 51 with other treatments to treat ER-positive breast. Should I take on this thread you need to take tamoxifen daily for 5 years by an enzyme in liver... Much more protection than 3 years to new features see fewer ads and... And you decide that time is now a lot to ask Mumsnet has n't checked the of. Game is n't always enough to make, the number of new cases of cancer cells is a lot people. Really know.When I started the side effects, 2017 in life Science long-term drug level reductions certain. Period ( menstrual ) cycle other treatments to treat certain types of breast cancer of 1 ( this thread 12. It eventually killed her at 51 be able to switch to another type of cancer is lowered @ Hey! More efficient in widespread use for over 30 years making a decision to start/stop again off the medication and know!