Objective To quantify the association of cancer treatment delay and mortality for each four week increase in delay to inform cancer treatment pathways. When combined with immunotherapy, the treatment was effective at eliminating tumors in mice. Research summary tables In our summary research tables, you can see findings from many studies on topics including breast cancer risk factors, screening, treatment, survivorship topics and social support. Understanding cancer research study design and how to … Because these newer therapies provide durable clinical benefits to only a small proportion of patients, new or revised therapeutic approaches must be developed. Injecting cells undergoing necroptosis, a form of cell death, into tumors in mice kickstarted an immune response against the tumors, researchers have found. About 80,000 compounds have been screened since 1990. Researchers are developing a new class of cancer drugs called radiopharmaceuticals, which deliver radiation therapy directly and specifically to cancer cells. They also found a natural compound, I3C, that in lab studies could flip the on switch. A new study has linked age with how well patients with melanoma responded to treatment with immune checkpoint inhibitors. A new study has found the commonly used chemotherapy drug cisplatin is retained in the inner ear of mice and humans for long periods. Could A Form of Cell Death Enhance Cancer Immunotherapy? ... Cancer Research UK is a registered charity in England and Wales (1089464), Scotland (SC041666), the Isle of Man (1103) and Jersey (247). Explore some of the most intensively pursued research topics at Memorial Sloan Kettering. A study in mice may have identified a way to help overcome resistance to targeted cancer drugs known as PI3K inhibitors. NCI’s Dr. Lyndsay Harris provides an update on the NCI-MATCH trial, including the opening of new trial treatment arms and the addition of new laboratories to perform testing on tumor samples of prospective trial participants. The FDA has cleared a cooling cap—a device designed to reduce hair loss during chemotherapy called the DigniCap Scalp Cooling System—for use by patients with any type of solid tumor. Additional cancer treatment innovations are on the horizon. Researchers who study exceptional responders—patients who have dramatic and long-lasting responses to treatments for cancer that were not effective for most similar patients—met recently to discuss the state of the science in this emerging field. A new NCI-supported study showed that altering cancer cell metabolism by feeding mice a diet very low in the nutrient methionine improved the ability of chemotherapy and radiation therapy to shrink tumors. Dr. Judith Paice, of the Cancer Pain Program at Northwestern University’s Feinberg School of Medicine, discusses the impacts of the opioid epidemic on cancer patients and how providers can address concerns about opioid misuse when managing cancer pain. In this pilot study, patients with KSHV-associated multicentric Castleman disease will receive intravenous tocilizumab every other week for up to 12 weeks. NExT: Advancing Promising Cancer Therapies from the Lab to Clinical Trials, Biosimilars for Cancer Emerge as Patents on Widely Used Biological Drugs Expire, New approach to immunotherapy leads to complete response in breast cancer patient unresponsive to other treatments, NCI-MATCH precision medicine clinical trial releases new findings, strengthens path forward for targeted cancer therapies, Cancer Immunotherapy Drug Simultaneously Targets Two Proteins that Block Immune Response, Targeted Therapy Larotrectinib Shows Promise in Early Trials, Regardless of Cancer Type, New Cancer Treatment Approach Targets Circadian Clock, Oncolytic Virus Therapy: Using Tumor-Targeting Viruses to Treat Cancer, Gut Bacteria Influence Effectiveness of a Type of Immunotherapy, Study Identifies Potential Cause of Hearing Loss from Cisplatin, Acupuncture May Reduce Treatment-Related Joint Pain for Breast Cancer Patients, Fat Cells May Hinder Effectiveness of Chemotherapy, Expanding Cancer Clinical Trial Access for Patients with HIV, Liquid Biopsy: Using DNA in Blood to Detect, Track, and Treat Cancer, Timing and Sequence Critical for Immunotherapy Combination, Forgoing Conventional Cancer Treatments for Alternative Medicine Increases Risk of Death, Study Uncovers Previously Unrecognized Effect of Chemotherapy, Ibrutinib Becomes First FDA-Approved Drug for Chronic Graft-Versus-Host Disease, NCI study identifies essential genes for cancer immunotherapy, FDA Clears Wider Use of Cooling Cap to Reduce Hair Loss during Chemotherapy, Cancer Researchers Report Progress in Studying Exceptional Responders, Understanding “Chemobrain” and Cognitive Impairment after Cancer Treatment, U.S. Department of Health and Human Services. Research has shown how well these drugs can delay cancer growth, in many cases by years. A new study conducted primarily in mice suggests that chemotherapy given before surgery for breast cancer can cause changes in cells in and around the tumor that are tied to an increased risk of the cancer spreading to other areas of the body. All patients with cancer will have safe and effective treatments. Some experts believe that proton therapy is safer than traditional radiation, but research has been limited. In a new study, the virus provided T cells around tumors with a hormone they need for their own cell-killing functions. Research studies show tests that analyze tumor DNA in blood, called liquid biopsies, may help detect cancer early, guide precision cancer treatment, and track treatment response. Earlier Treatments These newer drugs were first approved for use only after other treatments stopped working. Cancer.net website. Researchers have identified proteins that may play a central role in transforming T cells from powerful destroyers to depleted bystanders that can no longer harm cancer cells. Percy Ivy and Louis Staudt of NCI analyzed tumor tissue—and normal tissue, when available—from 111 patients enrolled in the initiative. Despite the tremendous progress made in recent decades in treating many types of cancer, effective therapies are still lacking for some forms of the disease, including liver cancer, pancreatic cancer, and certain types of adult and pediatric brain cancer. American Cancer Society website. Off Target: Investigating the Abscopal Effect as a Treatment for Cancer, Overcoming a Cancer Nemesis? Results from a clinical trial suggest that, in patients with brain metastases, an advanced radiotherapy technique limits harm to patients’ cognitive function without affecting the treatment’s effect on tumors. Improving Cancer Immunotherapy: Overcoming the Problem of ‘Exhausted’ T Cells, Helping Dogs—and Humans—with Cancer: NCI’s Comparative Oncology Studies, Researchers Turn On PTEN Tumor-Suppressor Protein in Cancer Cells, When Cancer Spreads to Bone, A Single Dose of Radiation Therapy May Control Pain, New Drugs, New Side Effects: Complications of Cancer Immunotherapy, Immunotherapy Drug with Two Targets Shows Promise against HPV-Related Cancers, Treating KSHV-Associated Multicentric Castleman Disease, Harnessing T-cell “stemness” could enhance cancer immunotherapy. FDA has approved entrectinib (Rozlytrek) for the treatment of children and adults with tumors bearing an NTRK gene fusion. Researchers are investigating factors that might predict who’s more at risk for experiencing “chemobrain” after cancer treatment and what can be done to lessen its impact. Many other important research opportunities exist to improve the care and treatment of the individual patient. An experimental drug may help prevent the chemotherapy drug doxorubicin from harming the heart and does so without interfering with doxorubicin’s ability to kill cancer cells, according to a study in mice. Because of the multifactorial nature of drug resistance and the high cost of clinical trials of novel drugs, many challenges arise for translational research to identify new, effective therapeutic targets that can be applied for the treatment of cancer with adaptive resistance. Cancer Metabolism. Using mouse models of cancer, researchers found that altering the gut microbiome could affect whether tumors responded to checkpoint inhibition. New findings from a clinical trial suggest that a single dose of radiation therapy may control painful bone metastases as effectively as multiple lower doses of radiation therapy. NCI is developing the capability to produce cellular therapies, like CAR T cells, to be tested in cancer clinical trials at multiple hospital sites. ... MSK is now offering COVID-19 vaccine to patients age 65 and over who live in New York State and are in active treatment with MSK on or after 1/1/20. Post-menopausal women with breast cancer should receive genetic testing for high-risk cancer … KRAS Inhibitor Shows Promise in Early Trial, Dual-Function Virus Engineered to Kill Tumor Cells and Support Immune Cells, FDA Approves Entrectinib Based on Tumor Genetics Rather Than Cancer Type, Altering Diet Enhances Response to Cancer Treatments in Mice, Study Tests Immunotherapy in People with Cancer and Autoimmune Diseases, Newly Discovered ‘Don’t Eat Me’ Signal May be a Target for Cancer Immunotherapy, CAR T Cells: Engineering Patients’ Immune Cells to Treat Their Cancers. This year, focus at the ASCO Annual Meeting has been on a type of immunotherapy called PD-1 inhibitors. Fully realizing the potential to identify, study, and test new cancer therapies requires additional research to achieve the following goals: Treatments that target the molecular changes in a person’s cancer and immunotherapies that unleash the power of the immune system against the disease are revolutionizing the potential of cancer care. Study finds elevated risk of certain rare blood cancers after chemotherapy for most solid tumors, Tailored Radiation to Treat Brain Metastases Reduces Impact on Cognitive Function, NCI-MATCH Update: More Labs, New Arms, and Initial Findings, Heart Problems: Investigating the Cardiac Side Effects of Cancer Treatments, Integrating Geriatric Assessment into Cancer Care: A Conversation with Dr. Supriya Mohile, High-Fat Diet or Diabetes Drug May Enhance Response to Targeted Cancer Drug, Mouse Study Links Immune Cells to Diarrhea Caused by Chemotherapy, The Opioid Epidemic and Cancer Pain Management: A Conversation with Dr. Judith Paice. 2018 was a remarkable year for cancer research, with great strides made in diagnosing and treating various types of cancer as well as important breakthroughs looking at the health of cancer … But Growing number of patients, new or revised therapeutic Approaches must be developed all cancer... 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