For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. My Collie is double MDR1 mutant. Frontline Gold and Frontline Shield. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Any suggestions? SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. The MDR1 mutation is most commonly seen in herding breeds. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Is this vaccine something youve heard of? (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. As with any topical, of course keep an eye out for skin irritation. This year she has a very high degree of irritation when applied (I had to wash it off). I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Thank you again for all your help : ). Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. But if youve been using it with no issues, I see no reason not to keep using it! Hello! In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Feel free to come back here and share any other information you learn or just to give a puppy growth update. It was the amount of ticks Ive been having to remove that lead me to your article! It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. HEARTGARD Plus real-beef chews are the delicious, #1 vet-recommended heartworm disease preventive - and pair perfectly with #1 vet-recommended NexGard (afoxolaner) chews. If youre looking for something that will repel parasites, a product such as K9 Advantix II may make a good alternative. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. Thank you so much for writing this article!!! Because of their similarity to Heartgard, Ive placed them in the same caution category. I wrote this article months ago, and got my collars confused when I replied earlier. The main goal of this medication, according to the FDA, is; Tap to zoom. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. 1x 20mg tablet for 11.1 to 22 pounds. In a wellcontrolled 60day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60 visits was 99.0% and 99.7%, respectively, Fleas this summer in my part of CA are particularly bad. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Buy Simparica Trio for Small dogs 5.1-10Kg. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. THANK YOU, THANK YOU, THANK YOU! The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! Hi, Thank you for this helpful article. An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. After her first heat she went into a false pregnancy. Basically, the idea is that heartworms take a few months to develop anyway, so every few months you get your dog tested instead of merely annually and ONLY treat for heartworms if bloodwork reveals that your dog has contracted heartworms. I follow this advice, since Im a safe-is-better-than-sorry person. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Super useful research. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. Either way, I certainly dont want to risk it for him again. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Review this. So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. All but one (5 of 6) of the Simparica Trio-treated dogs were negative for D. immitis antigen and MF on day 180, while the remaining dog was positive for the antigen but negative for MF for this day. I had never heard of Dimmitrol before, but I did some research after reading your comment. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. Are you also on Instagram, by chance? Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? They both have tolerated Bravecto very well.no noticeable side effects. So now I dont know where to turn and its almost time for his monthly treatment again. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. The FDA issued an alert to owners and veterinarians and said it was requiring clearer labels on the products. Congratulations and good luck with your new dog! That is my concern. Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. But it doesnt hurt mammals. The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. However, not all MLs are created equal, and some are safer than others. Thank you for your very informative article. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. This product is an awesome all in one, monthly chewable tablet. Im glad you found this information helpful. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. Wash hands after handling the product. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. I was unaware of MDR1 Mutation drug reactions at the time. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. thanks for your research. Thank you for the research and the detailed info on each product. Im just looking for advice as to tick prevention medication. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! for, I think its brown ticks. Simparica Trio 11.1-22 lbs. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. Thank you! Your thoughts? Im going to order some of the organic spray to help. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. He had been taking the it for about 2-3 months. I just picked out a beautiful tri color rough collie this morning! From what youve told me, that does sound highly suspect. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! The accidental ingestion of the product may potentially result in . As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. Giardia can be passed to and cause diarrhea in humans. (This is for all dogs, not just for dog breeds at-risk for MDR1.) We can eat it. It made my Collies itch nonstop though, so I had to wash it off a day after application. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. 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