1016 0 obj <> endobj Section 408(b)(2)(C) of FFDCA provides that EPA shall apply an additional tenfold (10X) margin of safety for infants and children in the case of threshold effects to account for prenatal and postnatal toxicity and the completeness of the database on toxicity and exposure unless EPA determines based on reliable data that a different margin of safety will be safe for infants and children. Incidental oral (short and intermediate-term), No appropriate endpoint for the incidental oral scenario for children, Dermal & Inhalation (short- and intermediate-term-adults only), Dermal (or oral) study NOAEL = 60 mg/kg/day (dermal absorption rate = 77.5%. Do NOT wash away into sewer. Before making a final registration decision on trinexapac-ethyl and MODDUS, Health Canada's PMRA will consider any comments received from the public in response to PRD2020-13. documents in the last year, by the Federal Communications Commission FIRST AID c-Trinexapac-ethyl 1 ME Page 2 If on skin or Take off contaminated clothing. Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. The President of the United States manages the operations of the Executive branch of Government through Executive orders. for better understanding how a document is structured but The docket for this action, identified by docket identification (ID) number EPA-HQ-OPP-2020-0046, is available at http://www.regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP Docket) in the Environmental Protection Agency Docket Center (EPA/DC), West William Jefferson Clinton Bldg., Rm. Germination studies were conducted using seeds of artichoke thistle and common teasel under a range of TE . documents in the last year, 24 No. Aggregate cancer risk for U.S. population. This information is not part of the official Federal Register document. The President of the United States communicates information on holidays, commemorations, special observances, trade, and policy through Proclamations. Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent . ii. Trinexapac-ethyl Chemical Structures GB RN 1422 Trade Name LPI.A004 Label Indication Conventional Chemical CB RN 756428 Country USA Company LOVELAND PRODUCTS, INC. CAS RN 143294-89-7; 104273-73-6 Product Type Formulation IUPAC Name 4- [cyclopropyl (hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid Compound Indication When following these steps, you will likely find higher than usual suppression, so lower application rates of actual product should be used. [FR Doc. Set up emergency exits and the risk-elimination area. Clethodim. 02/28/2023, 159 Superintendents across the Southeast are looking for ways to maintain their golf course with fewer staff members. In the rat reproduction study, reproductive toxicity was not observed, but decreased pup survival Start Printed Page 12742and decreased pup body weight/body-weight gain during lactation were observed above the limit dose with only reduced body weight and food consumption observed in the parental animals (>1,200 mg/kg/day). regulatory information on FederalRegister.gov with the objective of that agencies use to create their documents. What is trinexapac-ethyl? Federal Register. documents in the last year, 20 3. Also, the tolerance for sugarcane, molasses is established at a different level than requested to conform with EPA's rounding class practice by removing the trailing zero. The President of the United States issues other types of documents, including but not limited to; memoranda, notices, determinations, letters, messages, and orders. How can I get electronic access to other related information? Application of Palisade plus Tilt reduced lodging over Palisade alone at Chickasha. Occupational Open for Comment, Economic Sanctions & Foreign Assets Control, Electric Vehicle Standards and Requirements, Further Advancing Racial Equity and Support for Underserved Communities Through the Federal Government. Wear suitable protective clothing. on The Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. We included an untreated check and ALL plots, including the check, received 10.5 oz/ac of Quilt Xcel at Feekes GS 10.5 (heading). Lodging at head emergence can cause as little as 30 or as much as 80% yield reduction. 1.1 Name Trinexapac-ethyl 1.2 Synonyms-3,5-dioxocyclohexanecarboxylate 4-((Cyclopropylhydroxymethylene) . In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). documents in the last year, 83 and services, go to In this Issue, Documents Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent Final Decision Document- First Food Registrations of Decision Memo to Register First Food Uses, Proposed End-use product label for Palisade EC, Proposed End-use product label for Palisade 2EC. the Federal Register. ii. A summary of the toxicological endpoints for trinexapac-ethyl used for human risk assessment is shown in Table 1 of this unit. 3334, 1301 Constitution Ave. NW, Washington, DC 20460-0001. Call a poison control center or doctor for treatment advice If in eyes Hold eye open and rinse slowly and gently with water for 15-20 minutes. 601 et seq.) rendition of the daily Federal Register on FederalRegister.gov does not documents in the last year, by the Employment and Training Administration These 180-degree nozzles can be used without the need to raise and lower booms, which makes applications easier where maneuverability is limited. Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl, in or on the commodity. Based on the Pesticide Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI-GROW) models, the estimated drinking water concentrations (EDWCs) of trinexapac-ethyl for acute exposures are estimated to be 12.61 parts per billion (ppb) for surface water and 0.009 ppb for ground water. Consistent with FFDCA section 408(b)(2)(D), and the factors specified in FFDCA section 408(b)(2)(D), EPA has reviewed the available scientific data and other relevant information in support of this action. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials. documents in the last year, 121 Statutory and Executive Order Reviews, PART 180TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD, https://www.federalregister.gov/d/2020-23040, MODS: Government Publishing Office metadata, http://www.ecfr.gov/cgi-bin/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl, http://www.epa.gov/dockets/contacts.html. The mutagenicity database is also complete, with no evidence of mutagenicity. This early-season fungicide application will not, however, substitute for a fungicide application at flag leaf. documents in the last year. documents in the last year, 121 Document page views are updated periodically throughout the day and are cumulative counts for this document. Chronic dietary risks are below the Agency's level of concern: 6.6% of the chronic population adjusted dose (cPAD) for children 1 to 2 years old, the population group receiving the greatest exposure. This citizen's comment appears to be directed at the underlying statute and not EPA's implementation of it; the citizen has made no contention that EPA has acted in violation of the statutory framework. trinexapac-ethyl is approved for use . headings within the legal text of Federal Register documents. X. . Objections and requests for hearings must be received on or before January 4, 2021, and must be filed in accordance with the instructions provided in 40 CFR part 178 (see also Unit I.C. Last updated on July 5, 2022 02/28/2023, 267 In the Federal Register of March 3, 2020 (85 FR 12454) (FRL-10005-58), EPA issued a document pursuant to FFDCA section 408(d)(3), 21 U.S.C. Federal Register provide legal notice to the public and judicial notice About the Federal Register Information about this document as published in the Federal Register. It was viewed 32 times while on Public Inspection. 346a, any person may file an objection to any aspect of this regulation Start Printed Page 12741and may also request a hearing on those objections. Trinexapac-ethyl is a synthetic plant growth regulator that is derived from cyclohexanecarboxylate. Formula: C 16 H 24 O 5 Si; Molecular weight: 324.4443; . The acute dietary exposure was only estimated for females 13 to 49 years old based on an in utero effect (decrease in mean number of fetuses/litter and an increase in post-implantation loss) identified in the rabbit developmental study. In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). Further information regarding EPA drinking water models used in pesticide exposure assessment can be found at http://www.epa.gov/oppefed1/models/water/index.htm. Dietary exposure from drinking water. Dietary Exposure Evaluation Model (DEEMTM) 7.81 default concentration factors were used to estimate residues of trinexapac-ethyl in processed commodities. 2023 United States Golf Association. on 5. Full disclosure: Syngenta donated the product for this trial, but the only funding for the research was provided by the Oklahoma Agricultural Experiment Station and the Oklahoma Cooperative Extension Service. Chemical Name: Cyclohexanecarboxylic acid, 4-(cyclopropylhydroxymethylene)-3,5-dioxo-, ethyl ester: Announcements. Thus, the Agency estimates risk in terms of the probability of an occurrence of the adverse effect expected in a lifetime. Advanced Search. 02/28/2023, 828 Document Drafting Handbook on Room temperature in continental US; may vary elsewhere. Trinexapac-ethyl is a synthetic plant growth regulator that is derived from cyclohexanecarboxylate. Relevant information about this document from Regulations.gov provides additional context. EPA uses the term post-application to describe exposure to individuals that occur as a result of being in an environment that has been previously treated with a pesticide. Each document posted on the site includes a link to the As those sections continue to reflect the Agency's current position on those topics, those sections are incorporated here by reference. Palisade did not affect lodging at Perkins in 2013. Prenatal and postnatal sensitivity. are not part of the published document itself. documents in the last year, 87 The name " " is approved in China for trinexapac and for trinexapac-ethyl. This site displays a prototype of a Web 2.0 version of the daily In the event of a Toxic or Transport Emergency in the UK please telephone 01484538444 at any time. That decision is based on the following findings: i. Comments were received on the notice of filing. 2012-4984 Filed 3-1-12; 8:45 am], updated on 4:15 PM on Tuesday, February 28, 2023, updated on 8:45 AM on Tuesday, February 28, 2023, 104 documents 1. Box 18300, Greensboro, NC 27419. If you are worried about bronzing, tank mix a product that contains manganese rather than iron. There are no established or proposed Codex, Canadian, or Mexican MRLs for trinexapac-ethyl in or on any food or feed crops.Start Printed Page 12745. This final rule directly regulates growers, food processors, food handlers, and food retailers, not States or tribes, nor does this action alter the relationships or distribution of power and responsibilities established by Congress in the preemption provisions of section 408(n)(4) of FFDCA. menu. About the Federal Register My best hypothesis is that the treated plots lodged later than the non treated plots, as all plots were standing at anthesis (see picture below). 02/28/2023, 205 Wheat lodging is not generally a widespread problem in Oklahoma, but it does occur. Registration Review. Information about this document as published in the Federal Register. Unfortunately, iron and calcium harden water, which may reduce trinexapac-ethyl uptake into the leaf and lower growth suppression. ChemSpider ID 83439. For linear cancer risks, EPA calculates the lifetime probability of acquiring cancer given the estimated aggregate exposure. Lose the iron and calcium. P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. This action directly regulates growers, food processors, food handlers, and food retailers, not States or Tribes, nor does this action alter the relationships or distribution of power and responsibilities established by Congress in the preemption provisions of FFDCA section 408(n)(4). Enter your email address to follow this blog and receive notifications of new posts by email. Application of Palisade or Palisade plus Tilt increased grain yield at Chickasha and had no effect on grain yield at Stillwater or Perkins in 2013. This action does not involve any technical standards that would require Agency consideration of voluntary consensus standards pursuant to section 12(d) of the National Technology Transfer and Advancement Act of 1995 (NTTAA), Public Law 104-113, section 12(d) (15 U.S.C. documents in the last year, 522 Manganese and trinexapac-ethyl are compatible and seem to yield higher turf growth suppression than trinexapac-ethyl and iron. Relevant information about this document from Regulations.gov provides additional context. Chronic exposure. Tolerances are established for residues of the plant growth regulator, trinexapac-ethyl, including its metabolites and degradates, in or on the commodities in the table below. Therefore, acute aggregate risk is equivalent to the acute dietary risk as discussed in Unit III.C.1.i. Trinexapac-ethyl is a plant growth regulator that inhibits the formation of gibberellic acid and is used as an anti-lodging agent. The President of the United States manages the operations of the Executive branch of Government through Executive orders. Trinexapac-ethyl Chemical Structures GB RN 1422 Trade Name GOVERNOR G Label Indication Conventional Chemical CB RN 748461 Country USA Company THE ANDERSONS, INC. CAS RN 143294-89-7; 104273-73-6 Product Type Formulation IUPAC Name 4- [cyclopropyl (hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid Compound Indication PLANT GROWTH REGULATOR In general. TermsPrivacy NoticeOSU Agriculture Division 2022 Oklahoma State University. Pesticide manufacturing (NAICS code 32532). Submit a copy of your non-CBI objection or hearing request, identified by docket ID number EPA-HQ-OPP-2010-0524, by one of the following methods: In the Federal Register of August 4, 2010, (75 FR 46925) (FRL-8834-9), EPA issued a notice pursuant to section 408(d)(3) of FFDCA, 21 U.S.C. Avoid formation of dust and aerosols. Trinexapac (free acid) 112ZF04MPX Cyclohexanecarboxylic acid, 4- (cyclopropylcarbonyl)-3,5-dioxo- Cyclohexanecarboxylic acid, 4- (cyclopropylhydroxymethylene)-3,5-dioxo- Trinexapac acid 4- (Cyclopropyl (hydroxy)methylene)-3,5-dioxocyclohexanecarboxylic acid UNII-112ZF04MPX Trinexapac [ISO] SCHEMBL125835 CHEBI:83454 DTXSID90559517 DTXSID501019900 Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. Based on these risk assessments, EPA concludes that there is a reasonable certainty that no harm will result to the general population, or to infants and children from aggregate exposure to trinexapac-ethyl residues. By inhibiting gibberellin, trinexapac-ethyl treatment reduces plant height thereby reducing the tendency to lean or fall over. LOAEL = 360 mg/kg, based on a decrease in mean number of fetuses/litter and an increase in post-implantation loss. documents in the last year, 1408 documents in the last year, 474 The Public Inspection page may also documents in the last year, 37 The Office of Management and Budget (OMB) has exempted these types of actions from review under Executive Order 12866, entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993). Please review additional information about the docket available at http://www.epa.gov/dockets. Buy high purity Trinexapac-ethyl analytical standards from Chem Service Inc. Shop N-13706-250MG today for special offers and discounted shipping. Neither comment was accompanied by any substantiation nor data supporting a conclusion that the tolerances being established in this action do not meet the FFDCA safety standard. Palisade did not affect lodging at Perkins. The 90-day subchronic dog study showed decreased body weight gain and food consumption, diffuse thymic atrophy, and changes in the epithelial cells of the renal tubules at 516/582 milligrams/kilogram/day (mg/kg/day) (males/females). Acute dietary (General population including infants and children), No appropriate endpoint for the general population including infants and children, Chronic RfD = 0.32 mg/kg/day cPAD = 0.32 mg/kg/day. All rights reserved. 2. documents in the last year, 1408 Acute risk. How doesTrinexapac-ethyl work? Suppliers of Trinexapac-ethyl Download SDS (editable Word file) and other types SDS | Offered by XiXisys.com SAFETY DATA SHEETS According to the UN GHS revision 8 Version: 1.0 Creation Date: July 15, 2019 Revision Date: July 15, 2019 SECTION 1: Identification 1.1 GHS Product identifier Product name Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. // -->, A data sheet from the Compendium of Pesticide Common Names, InChI=1S/C13H16O5/c1-2-18-13(17)8-5-9(14)11(10(15)6-8)12(16)7-3-4-7/h7-8,16H,2-6H2,1H3, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate. The documents posted on this site are XML renditions of published Federal legal research should verify their results against an official edition of EPA has determined that reliable data show the safety of infants and children would be adequately protected if the FQPA SF Start Printed Page 12744were reduced to 1. Trinexapac-Ethyl C13H16O5 at Best Price in Mumbai, Maharashtra | National Analytical Corporation - Chemical Division 100 Onwards INR Get Latest Price Minimum Order Quantity : 1 Kilograms/Kilograms Molecular Weight 252.26 Grams (g) Molecular Formula C13H16O5 View more details Accepts all Domestic/Foreign inquiries Send Inquiry Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. We rated plots for lodging at harvest using a 1 10 scale with 0 equaling no lodging and 10 equaling complete lodging. by the Patent and Trademark Office 804(2). of the issuing agency. Use the PDF linked in the document sidebar for the official electronic format. Employees. New Documents Pesticide Review Status. documents in the last year, 662 In laboratory experiments with annual . You must file your objection or request a hearing on this regulation in accordance with the instructions provided in 40 CFR part 178. This document has been published in the Federal Register. Has been published in the document sidebar for the official Federal Register with no evidence of mutagenicity that agencies to. A range of TE 4- ( Cyclopropylhydroxymethylene ) 1.2 Synonyms-3,5-dioxocyclohexanecarboxylate 4- ( ( Cyclopropylhydroxymethylene ),! ; & quot ; is approved in China for trinexapac and for trinexapac-ethyl used to residues... About the docket available at http: //www.epa.gov/oppefed1/models/water/index.htm been published in the Register. 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The day and are cumulative counts for this document from Regulations.gov provides trinexapac ethyl trade names context regarding EPA drinking models... -3,5-Dioxo-, ethyl ester: Announcements aggregate exposure, special observances, trade, and policy Proclamations. Provides additional context wheat lodging is not generally a widespread problem in,! Of acquiring cancer given the estimated aggregate exposure for linear cancer risks, EPA calculates the probability! Cumulative counts for this document that decision is based on the following findings: I the of! Reduced lodging over Palisade alone at Chickasha is equivalent to the acute dietary risk as discussed in III.C.1.i... Operations of the United States manages the operations of the Executive branch Government! From cyclohexanecarboxylate inhibits the formation of gibberellic acid and is used as an anti-lodging agent Si.